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Scientific Publications

Relevant equine exercise genomics related publications by Equinome scientists:

(Please note that not all titles are available to download due to individual publisher restrictions)

2012

Truth in the bones: resolving the identity of the founding elite Thoroughbred racehorses.

Bower MA, Campana MG, Nisbet RER, Weller R, Whitten M, Edwards CJ, Stick F, Barrett E, O'Connell TC, Hill EW, Wilson AW, Howe CJ, Barker G, Binns M. Archaeometry, 2012, doi: 10.1111/j.1475-4754.2012.00666.x

MSTN genotypes in Thoroughbred horses influence skeletal muscle gene expression and racetrack performance.

McGivney BA, Browne JA, Fonseca RG, Katz LM, MacHugh DE, Whiston R, Hill EW. Animal Genetics, 2012 Early View 27 Feb 2012 doi: 10.1111/j.1365-2052.2012.02329.x

The genetic origin and history of speed in the Thoroughbred racehorse.

Bower MA, McGivney BA, Campana MG, Gu J, Andersson LS, Barrett E, Davis CR, Mikko S, Stock F, Voronkova V, Bradley DG, Fahey AG, Lindgren G, MacHugh DE, Sulimova G, Hill EW. Nature Communications, 2012, 3:643 doi: 10.1038/ncomms1644

A High Density SNP Array for the Domestic Horse and Extant Perissodactyla: Utility for Association Mapping, Genetic Diversity and Phylogeny Studies.

McCue ME et al. PLoS Genetics, 2012 8(1): e1002451. doi:10.1371/journal.pgen.1002451

2011

MSTN genotype (g.66493737C/T) association with speed indices in Thoroughbred racehorses.

Hill EW, Fonseca RG, McGivney BA, Gu J, MacHugh DE, Katz LM. Journal of Applied Physiology, 2011 Oct 20.

PGC-1α encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise.

Eivers SS, McGivney BA, Gu J, MacHugh DE, Katz LM and Hill EW. Animal Genetics, In Press July 2011

Sequence variants at the myostatin gene locus influence the body composition of Thoroughbred horses.

Tozaki T, Sato F, Hill EW, Miyake T, Endo Y, Kakoi H, Gawahara H, Hirota K, Nakano Y, Nanbo Y, Kurosawa M Journal of Veterinary Science, 2011 73(12): 1617-1624, 2011

A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18.

Tozaki T, Hill EW, Hirota K, Kakoi H, Gawahara H, Miyake T, Sugita S, Hasegawa T, Ishida N, Nakano Y, Kurosawa M. Animal Genetics, Advanced On-line Publication April 19 2011

2010

Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle.

Hill EW, Eivers SS, McGivney, Fonseca RG, GU J, Smith NA, Browne JA, MacHugh DE, Katz LM. Equine Veterinary Journal, 2010 42 Suppl s38:576-581

Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses.

Gu J, MacHugh DE, McGivney BA, Park SDE, Katz LM, Hill EW. Equine Veterinary Journal, 2010 42 Suppl s38:569-575

The association of various speed indices to training responses in Thoroughbred flat racehorses measured with a global positioning and heart rate monitoring system.

Fonseca RG, Kenny D, Hill EW and Katz LM. Equine Veterinary Journal, 2010 42 Suppl s38:51-57

Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance.

Hill EW, Gu J, McGivney BA, MacHugh DE. Animal Genetics. 2010. 41 (Suppl. 2), 56-63

A genome-wide SNP-association study confirms a sequence-variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses.

Hill EW, McGivney BA, Gu J, Whiston R, Machugh DE. BMC Genomics. 2010 Oct 11;11(1):552

The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish mares.

M. A. Bower, M. G. Campana, M. Whitten, C. J. Edwards, H. Jones, E. Barrett, R. Cassidy, R. E. R. Nisbet, E. W. Hill, C. J. Howe, M. Binns. Biology Letters. 2010 Oct 06;10.1098

Circadian regulation of locomotor activity and skeletal muscle gene expression in the horse.

AM Martin, JA Elliott, P Duffy, CM Blake, SB Attia, LM Katz, JA Browne, V Gath, BA McGivney, EW Hill, BA Murphy. J Appl Physiol. 2010 Sep 16;10.1152

Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training.

McGivney BA, McGettigen PA, Browne JA, Evans ACO, Fonseca RG, Loftus BJ, Lohan A, MacHugh DE, Murphy BA, Katz LM, Hill EW. BMC Genomics. 2010 Jun 23;11:398.

A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in Thoroughbred horses.

Hill EW, Gu J, Eivers SS, Fonseca RG, McGivney BA, Govindarajan P, Orr N, Katz LM, MacHugh DE. PLoS One. 2010 Jan 20;

2007-2009

Transcriptional modifications following exercise in Thoroughbred horse skeletal muscle highlight molecular mechanisms that lead to muscle hypertrophy.

McGivney BA, Eivers SS, MacHugh DE, Macleod JN, O'Gorman GM, Park SD, Katz LM, Hill EW. BMC Genomics. 2009 Dec 30;10(1):638.

Genome sequence, comparative analysis, and population genetics of the domestic horse.

Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, Mauceli E, MacLeod JN, Penedo MC, Raison JM, Sharpe T, Vogel J, Andersson L, Antczak DF, Biagi T, Binns MM, Chowdhary BP, Coleman SJ, Della Valle G, Fryc S, Guérin G, Hasegawa T, Hill EW, Jurka J, Kiialainen A, Lindgren G, Liu J, Magnani E, Mickelson JR, Murray J, Nergadze SG, Onofrio R, Pedroni S, Piras MF, Raudsepp T, Rocchi M, Røed KH, Ryder OA, Searle S, Skow L, Swinburne JE, Syvänen AC, Tozaki T, Valberg SJ, Vaudin M, White JR, Zody MC; Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team, Lander ES, Lindblad-Toh K. Science. 2009 Nov 6;326(5954):865-7.